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20, 2024, the FDA approved tirzepatide (Zepbound) for the treatment of moderate-to-severe OSA in adults with obesity, with and without positive airway pressure (PAP) therapy, making it the first GLP-1 indicated for OSA

Sienkiewicz E, Magkos F, Aronis KN, Brinkoetter M, Chamberland JP, Chou S, et al

120,121 In atherosclerosis, a metabolic disease driven by chronic inflammation and faulty lipid metabolism, E3 ligases such as FBXW2 and FBXO3 have been identified as key modulators of vascular inflammation